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New Approach to Cancer: Find Most Tightly Controlled Genes |
Scientists at a Duke University medical school in Singapore have found a new way to study cancer that could be very useful for developing targeted therapies against cancer and possibly many other diseases.
"Because all you need for this approach is gene expression data to compare both diseased and normal tissues, you could apply it to cancer or any other disease, if you have the data," said co-author and researcher Patrick Tan, M.D., Ph.D., associate professor of Duke-NUS Graduate Medical School Singapore. "Just replace the word 'cancer' with 'diabetes,' 'obesity,' and so on."
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Anchoring Protein Variant Associated with Increased Breast Cancer Risk |
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Individuals who carry a rare genetic variant have an increased risk of developing breast cancer over their lifetimes, compared with those who do not have the variant.
Few genes have been found to have a large impact on the risk of familial breast cancer, and researchers expect that most breast cancers are influenced by the combined effects of multiple genes, each of which has a small impact on its own. One of those genes may be AKAP9. |
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Even Tiny Breast Tumors Can Be Aggressive and May Require Maximum Therapy |
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Breast tumors that are 1 centimeter in size or smaller — no more than 0.4 inch in length — can still be very aggressive and may require more intensive therapy than is routinely offered today, say researchers at Mayo Clinic in Jacksonville, Fla.
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